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SolicitationsNIHPA-27-100
NIH
Grants.gov · SBIR · Phase I & II

PA-27-100 · NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)

NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) — an open NIH SBIR funding opportunity (PA-27-100), posted on Grants.gov.

Closes Agency portal
Typical administrative requirements11 requirements · confirm against the solicitation
Page limitsNIH How to Apply – Application GuideMECHANICAL
Technical-volume page limit set in the solicitation
The cap differs by program and phase — find it in the live solicitation; cover sheet, cost volume and commercialization material are typically excluded.
See NOFO
FontNIH How to Apply – Application GuideMECHANICAL
≥ 11 pt, no compression
Use a standard serif/sans face; condensed or narrow variants are commonly disallowed.
≥ 11 pt
MarginsNIH How to Apply – Application GuideMECHANICAL
≥ 0.5″ on all four sides
Margins are measured from the PDF page box and usually include headers and footers.
≥ 0.5″
Line spacingNIH How to Apply – Application GuideMECHANICAL
Single-spacing minimum
No more restrictive than single; tables and figures are typically exempt.
Single+
Required sectionsNIH How to Apply – Application GuideSEMANTIC
All mandated technical sections present
Match the solicitation's required structure and headings exactly — a mismatched heading is a known reject trigger.
Required
EligibilityNIH How to Apply – Application GuideSEMANTIC
US for-profit small business, ≤ 500 employees with affiliates
>50% US-owned and controlled by individuals; for SBIR the PI's primary employment must be with the firm at award.
SBC
Foreign ownershipNIH How to Apply – Application GuideSEMANTIC
FOCI / foreign-affiliation disclosure
Disclose foreign ownership, control or influence and the foreign affiliations of key personnel where required.
Disclose
RegistrationsNIH How to Apply – Application GuideSEMANTIC
SAM.gov + UEI active; SBC registry
Active SAM.gov registration and a valid Unique Entity ID at submission; SBA Company Registry for SBIR/STTR.
Active
Cost volumeNIH How to Apply – Application GuideSEMANTIC
Separate cost volume within the topic ceiling
Submitted separately from the technical volume and within the program/topic funding ceiling.
Separate
AI-use disclosureNIH How to Apply – Application GuideSEMANTIC
Disclose assistive AI use
Generative AI may typically assist with editing/formatting only; substantive content must be human-authored and any use disclosed where required.
If used
DeadlineNIH How to Apply – Application GuideMECHANICAL
Submit via the agency portal by Apr 5, 2027
The full electronic submission, including every volume, must be certified before the closing date/time.
Apr 5

Every NIH rule SolicitFit checks, with its source: NIH SBIR/STTR page limits, fonts and rules.

AI-use disclosure · NIH
SolicitFit checks compliance — it never writes your proposal.

Confirm this agency's AI-use policy in the current solicitation. Generative AI may typically assist with editing and formatting only; substantive content must be human-authored and any use disclosed where required.

The next step

Check your draft against PA-27-100

Paste this solicitation or upload the agency PDF to get the cited requirements matrix — then upload your draft for a line-item compliance report.

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SolicitFit audits your human-written draft for administrative compliance. It does not write proposal content and is not legal advice or a guarantee of acceptance. Don't upload classified / ITAR / CUI material.